NO-donors Stimulate [3H]Noradrenaline Release from Rat Hippocampal Slices
نویسندگان
چکیده
منابع مشابه
P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices.
This study was designed to test the hypothesis of whether activation of presynaptic P2X receptor-gated ion channels elicits noradrenaline release from central catecholaminergic terminals. ATP, alpha,beta-methylene-adenosine 5'-triphosphate (alpha,beta-methyleneATP), and ADP elicited concentration-dependent [3H]noradrenaline outflow from superfused rat hippocampal slices with the following rank ...
متن کاملOxiracetam increases the release of endogenous glutamate from depolarized rat hippocampal slices.
Nootropics are drugs employed to improve cognitive functions, particularly learning and memory ability, and to prevent their impairment following cerebral damage (Moos et al., 1988). Oxiracetam (4-hydroxy-2-oxopyrrolidinoacetamide) has been reported to enhance learning and memory in normal animals as well as in animals bearing different types of cerebral impairment. Clinical effects of oxiracet...
متن کاملExtracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slices.
The concentration of extracellular Ca2+ has been shown to enhance or attenuate [3H]acetylcholine (ACh) release subsequent to a conditioning stimulus in rat brain hippocampal slices. Slices were incubated in vitro in [3H]choline solution. Subsequently the slices were subjected to two consecutive electrical stimulations separated by 15 or 30 min at 0.25, 1, 4 and 16 Hz and [3H]ACh release was ass...
متن کاملBeta-amyloid-related peptides inhibit potassium-evoked acetylcholine release from rat hippocampal slices.
The 4 kDa beta-amyloid (A beta) protein, a major component of cerebral and cerebrovascular plaques in Alzheimer's disease (AD), is derived from the proteolytic cleavage of a larger, membrane-bound precursor, the A beta precursor protein (APP). Until recently, it was assumed that an aberrant AD-specific proteolysis generated A beta peptides, which subsequently could initiate and/or contribute to...
متن کاملMeasurement of Inositol Triphosphate Levels from Rat Hippocampal Slices.
Inositol triphosphate (IP3) is an important second messenger that participates in signal transduction pathways in diverse cell types including hippocampal neurons. Stimulation of phospholipase C in response to various stimuli (hormones, growth factors, neurotransmitters, neurotrophins, neuromodulators, odorants, light, etc) results in hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2),...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1995
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)46876-5